Article
A mouse model of early-onset renal failure due to a xanthine dehydrogenase nonsense mutation.
PloS one - 1 Jan 2012
Piret Sian E, Esapa Christopher T, Gorvin Caroline M, Head Rosie, Loh Nellie Y, Devuyst Olivier, Thomas Gethin, Brown Steve D M, Brown Matthew, Croucher Peter, Cox Roger, Thakker Rajesh V
Abstract excerpt
Chronic kidney disease (CKD) is characterized by renal fibrosis that can lead to end-stage renal failure, and studies have supported a strong genetic influence on the risk of developing CKD. However, investigations of the underlying molecular mechanisms are hampered by the lack of suitable hereditary models in animals. We therefore sought to establish hereditary mouse models for CKD and renal fibrosis by...
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