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Article

Mechanistic studies on histone catalyzed cleavage of apyrimidinic/apurinic sites in nucleosome core particles.

Journal of the American Chemical Society - 10 Oct 2012

Zhou Chuanzheng, Sczepanski Jonathan T, Greenberg Marc M

Abstract excerpt

Duplex DNA containing an apurinic/apyrimidinic (AP) lesion undergoes cleavage significantly more rapidly in nucleosome core particles (NCPs) than it does when free. The mechanism of AP cleavage within NCPs was studied through independently generating lesions within them. AP mediated DNA cleavage within NCPs is initiated by DNA-protein cross-link (DPC(un)) formation followed by β-elimination to give DPCs...

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PMID: 23020793
DOI: 10.1021/ja306858m
PMCID: PMC3477373

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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