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Article

Nucleosome core particle-catalyzed strand scission at abasic sites.

Biochemistry - 26 Mar 2013

Sczepanski Jonathan T, Zhou Chuanzheng, Greenberg Marc M

Abstract excerpt

The reactivity of apurinic/apyrimidinic (AP) sites at different locations within nucleosome core particles was examined. AP sites are greatly destabilized in nucleosome core particles compared to free DNA. Their reactivity varied ~5-fold with respect to the location within the nucleosome core particles but followed a common mechanism involving formation of a Schiff base between histone proteins and the lesion....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23480734
DOI: 10.1021/bi3010076
PMCID: PMC3718853

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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