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Article

Rapid DNA-protein cross-linking and strand scission by an abasic site in a nucleosome core particle.

Proceedings of the National Academy of Sciences of the United States of America - 28 Dec 2010

Sczepanski Jonathan T, Wong Remus S, McKnight Jeffrey N, Bowman Gregory D, Greenberg Marc M

Abstract excerpt

Apurinic/apyrimidinic (AP) sites are ubiquitous DNA lesions that are highly mutagenic and cytotoxic if not repaired. In addition, clusters of two or more abasic lesions within one to two turns of DNA, a hallmark of ionizing radiation, are repaired much less efficiently and thus present greater mutagenic potential. Abasic sites are chemically labile, but naked DNA containing them undergoes strand scission slowly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21149689
DOI: 10.1073/pnas.1012860108
PMCID: PMC3012510

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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