Article
Verification of the turn at positions 22 and 23 of the beta-amyloid fibrils with Italian mutation using solid-state NMR.
Bioorganic & medicinal chemistry - 15 Dec 2005
Masuda Yuichi, Irie Kazuhiro, Murakami Kazuma, Ohigashi Hajime, Ohashi Ryutaro, Takegoshi K, Shimizu Takahiko, Shirasawa Takuji
Abstract excerpt
The aggregation of 42-mer amyloid beta (Abeta42) plays a central role in the pathogenesis of Alzheimer's disease. Our recent research on proline mutagenesis of Abeta42 suggested that the formation of a turn structure at positions 22 and 23 could play a crucial role in its aggregative ability and neurotoxicity. Since E22K-Abeta42 (Italian mutation) aggregated more rapidly and with more potent neurotoxicity than...
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