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Methionine-35 of A<i>β</i>(1–42): Importance for Oxidative Stress in Alzheimer Disease

4 Jun 2011

Abstract excerpt

Alzheimer disease (AD) is an age-related progressive neurodegenerative disorder. This devastating disease is characterized by the presence of senile plaques (SP), neurofibrillary tangles (NFTs), and loss of synapses. Amyloid beta-peptide 1-42 (Aβ(1-42)) is the main component of SP and is pivotal to AD pathogenesis. Brain of subjects with AD and arguably its earliest manifestation, mild cognitive impairment (MCI),...

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PMID: 22312456
DOI: 10.4061/2011/198430

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