Article
MiR-125b orchestrates cell proliferation, differentiation and migration in neural stem/progenitor cells by targeting Nestin.
BMC neuroscience - 28 Sept 2012
Cui Yi, Xiao Zhifeng, Han Jin, Sun Jie, Ding Wenyong, Zhao Yannan, Chen Bing, Li Xiaoran, Dai Jianwu
Abstract excerpt
BACKGROUND: The emerging concept is that microRNAs (miRNAs) play a central role in controlling stem cell self-renewal and fate determination by regulating the expression of stem cell regulators. miR-125b, one of neuronal miRNAs, recently was found to be necessary for neural differentiation of neural stem/progenitor cells (NS/PCs). However, the other specific biological role of miR-125b in NS/PCs is little known....
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