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miR‐125b regulates the proliferation of glioblastoma stem cells by targeting E2F2

18 Sept 2012

Abstract excerpt

microRNAs (miRNAs) play important role in regulating cancer stem cell self-renewal and differentiation, but the expression prolife of miRNAs in glioma stem cells (GSCs) has not been addressed. Here, we found that CD133 positive GSCs possess a unique miRNAs profile compared to CD133 negative glioblastoma cells. miR-125b, as one of neuronal miRNAs, is the most significantly down-regulated miRNAs and overexpression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22999819
DOI: 10.1016/j.febslet.2012.08.023

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