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Article

miR-125b Functions as a Key Mediator for Snail-induced Stem Cell Propagation and Chemoresistance

20 Dec 2012

Abstract excerpt

Chemoresistance is a major obstacle in cancer treatment. Our previous studies have shown that miR-125b plays an important role in chemoresistance. Here we report a novel mechanism that up-regulation of miR-125b through Wnt signaling by Snail enriches cancer stem cells. Overexpression of Snail dramatically increases the expression of miR-125b through the Snail-activated Wnt/β-catenin/TCF4 axis. Snail confers...

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PMID: 23255607
DOI: 10.1074/jbc.m112.419168

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