Article
Molecular genetic and structural modeling studies of Staphylococcus aureus RNA polymerase and the fitness of rifampin resistance genotypes in relation to clinical prevalence.
Antimicrobial agents and chemotherapy - 1 Jan 2006
O'Neill A J, Huovinen T, Fishwick C W G, Chopra I
Abstract excerpt
The adaptive and further evolutionary responses of Staphylococcus aureus to selection pressure with the antibiotic rifampin have not been explored in detail. We now present a detailed analysis of these systems. The use of rifampin for the chemotherapy of infections caused by S. aureus has resulte...
Topics
- DNA, Bacterial
- DNA-Directed RNA Polymerases
- Drug Resistance, Bacterial
- Genotype
- Humans
- Models, Molecular
- Mutation
- Prevalence
- Rifampin
- Staphylococcal Infections
- Staphylococcus aureus