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Article

Analysis of mupirocin resistance and fitness in Staphylococcus aureus by molecular genetic and structural modeling techniques.

Antimicrobial agents and chemotherapy - 1 Nov 2004

Hurdle Julian Gregston, O'Neill Alexander John, Ingham Eileen, Fishwick Colin, Chopra Ian

Abstract excerpt

Chromosomal resistance to mupirocin in clinical isolates of Staphylococcus aureus arises from V(588)F or V(631)F mutations in isoleucyl-tRNA synthetase (IRS). Whether these are the only IRS mutations that confer mupirocin resistance or simply those that survive in the clinic is unknown. Mupirocin-resistant mutants of S. aureus 8325-4 were therefore generated to examine their ileS genotypes and the in vitro and in...

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Identifiers

PMID: 15504866
DOI: 10.1128/AAC.48.11.4366-4376.2004
PMCID: PMC525403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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