Article
Site-directed mutations of the gatekeeping loop region affect the activity of Escherichia coli spermidine synthase.
Molecular biotechnology - 1 Jun 2013
Lee Mon-Juan, Yang Ya-Ting, Lin Vivian, Huang Haimei
Abstract excerpt
Spermidine synthase catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), and plays a crucial role in cell proliferation and differentiation. The gatekeeping loop identified in the structure of spermidine synthase was predicted to contain residues important for substrate binding, but its correlation with enzyme catalysis has not been fully understood. In this...
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