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Article

The nucleotide specificity of succinyl-CoA synthetase of Plasmodium falciparum is not determined by charged gatekeeper residues alone.

FEBS open bio - 1 Mar 2021

Vashisht Kapil, Singh Pallavi, Verma Sonia, Dixit Rajnikant, Mishra Neelima, Pandey Kailash C

Abstract excerpt

Substrate specificity of an enzyme is an important characteristic of its mechanism of action. Investigation of the nucleotide specificity of Plasmodium falciparum succinyl-CoA synthetase (SCS; PfSCS) would provide crucial insights of its substrate recognition. Charged gatekeeper residues have been shown to alter the substrate specificity via electrostatic interactions with approaching substrates. The enzyme...

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Identifiers

PMID: 33174373
DOI: 10.1002/2211-5463.13034
PMCID: PMC7931218

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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