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Article

Rational design of small-molecule stabilizers of spermine synthase dimer by virtual screening and free energy-based approach.

PloS one - 1 Jan 2014

Zhang Zhe, Martiny Virginie, Lagorce David, Ikeguchi Yoshihiko, Alexov Emil, Miteva Maria A

Abstract excerpt

Snyder-Robinson Syndrome (SRS) is a rare mental retardation disorder which is caused by the malfunctioning of an enzyme, the spermine synthase (SMS), which functions as a homo-dimer. The malfunctioning of SMS in SRS patients is associated with several identified missense mutations that occur away from the active site. This investigation deals with a particular SRS-causing mutation, the G56S mutation, which was...

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Identifiers

PMID: 25340632
DOI: 10.1371/journal.pone.0110884
PMCID: PMC4207787

Genes

SMS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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