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Article

Connexin-32 acts as a downregulator of growth of thyroid gland.

American journal of physiology. Endocrinology and metabolism - 1 Feb 2008

Prost Gaëlle, Bernier-Valentin Françoise, Munari-Silem Yvonne, Selmi-Ruby Samia, Rousset Bernard

Abstract excerpt

Thyroid epithelial cells communicate through gap junctions formed from connexin (Cx)32, Cx43, and Cx26. We previously reported that reexpression of Cx32 in "gap junction-deficient" FRTL-5 and FRT thyroid cell lines induces a reduction of cell proliferation rate and an activation of expression of cell differentiation. The present study aimed at determining whether Cx32 could exert similar regulatory functions in...

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Identifiers

PMID: 18042666
DOI: 10.1152/ajpendo.00281.2007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Connexin-32 acts as a downregulator of growth of thyroid gland.PMID 18042666Read ↗

Background lesions during a 24-month observation period in connexin 32-deficient mice.Semantic proximity Read ↗

Involvement of gap junctions in tumor suppression: analysis of genetically-manipulated mice.Semantic proximity Read ↗

Doubly mutant mice, deficient in connexin32 and -43, show normal prenatal development of organs where the two gap junction proteins are expressed in the same cells.Semantic proximity Read ↗

Delayed liver regeneration and increased susceptibility to chemical hepatocarcinogenesis in transgenic mice expressing a dominant-negative mutant of connexin32 only in the liver.Semantic proximity Read ↗

Both early and late stages of hepatocarcinogenesis are enhanced in Cx32 dominant negative mutant transgenic rats with disrupted gap junctional intercellular communication.Semantic proximity Read ↗

Gap junction proteins connexin32 and connexin43 partially acquire growth-suppressive function in HeLa cells by deletion of their C-terminal tails.Semantic proximity Read ↗

Cx40.8, a Cx43-like protein, forms gap junction channels inefficiently and may require Cx43 for its association at the plasma membrane.Semantic proximity Read ↗

Neoplastic phenotype of gap-junctional intercellular communication-deficient WB rat liver epithelial cells and its reversal by forced expression of connexin 32.Semantic proximity Read ↗

The effect of connexin32 null mutation on hepatocarcinogenesis in different mouse strains.Semantic proximity Read ↗

A spontaneously arising mutation in connexin32 with repeated passage of FRTL-5 cells coincides with increased growth rate and reduced thyroxine release.Semantic proximity Read ↗

WY-14,643-mediated promotion of hepatocarcinogenesis in connexin32-wild-type and connexin32-null mice.Semantic proximity Read ↗

Cell proliferation and advancement of hepatocarcinogenesis in the rat are associated with a decrease in connexin 32 expression.Semantic proximity Read ↗

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