Article
Mutational analysis of BRAF in fine needle aspiration biopsies of the thyroid: a potential application for the preoperative assessment of thyroid nodules.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2004
Cohen Yoram, Rosenbaum Eli, Clark Douglas P, Zeiger Martha A, Umbricht Christopher B, Tufano Ralph P, Sidransky David, Westra William H
Abstract excerpt
BACKGROUND: Fine needle aspiration (FNA) is routinely used in the preoperative evaluation of thyroid nodules, but subsequent patient management is often complicated by the inability to decisively recognize malignancy on cytologic grounds alone. Activating mutations of the BRAF oncogene commonly occur in papillary thyroid carcinomas (PTCs) but not in other types of benign and malignant thyroid lesions. Mutational...
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