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Proteomic profiling of cancer stem cells derived from primary tumors of HER2/Neu transgenic mice

19 Sept 2012

Abstract excerpt

Human epidermal growth factor receptor 2 (HER2) overexpression leads to mammary tumorigenesis and its elevated levels lead to increase in cancer stem cells (CSCs), invasion, and metastasis. CSCs are resistant to radiation/chemotherapeutic drugs and are believed to be responsible for recurrence/relapse of cancer. CSCs are isolated using flow cytometry based sorting, although reliable, this technology hinders the...

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PMID: 22997041
DOI: 10.1002/pmic.201200103

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