Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD44: a key regulator of iron metabolism, redox balance, and therapeutic resistance in cancer stem cells

18 Apr 2025

Abstract excerpt

CD44, a multifunctional cell surface protein, has emerged as a pivotal regulator in cancer stem cell (CSC) biology, orchestrating processes such as stemness, metabolic reprogramming, and therapeutic resistance. Recent studies have identified a critical role of CD44 in ferroptosis resistance by stabilizing SLC7A11 (xCT), a key component of the antioxidant defense system, enabling CSCs to evade oxidative stress and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Ferroptosis and cancer prognosis
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40259468
DOI: 10.1093/stmcls/sxaf024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD44: a key regulator of iron metabolism, redox balance, and therapeutic resistance in cancer stem cellsPMID 40259468Read ↗

Intricate relationship between cancer stemness, metastasis, and drug resistanceSemantic proximity Read ↗

The Cancer Stem Cell Marker CD44 Play Key Roles in Immune Suppression/Evasion, Drug Resistance, Epithelial-Mesenchymal Transition, and Metastasis in Several Human CancersSemantic proximity Read ↗

Redox regulation of cancer stem cells: Biology and therapeutic implicationsSemantic proximity Read ↗

Molecular pathology underlying the robustness of cancer stem cellsSemantic proximity Read ↗

Cancer Stem Cell Marker CD44 Plays Multiple Key Roles in Human Cancers: Immune Suppression/Evasion, Drug Resistance, Epithelial–Mesenchymal Transition, and MetastasisSemantic proximity Read ↗

Transferrin receptor regulates malignancies and the stemness of hepatocellular carcinoma-derived cancer stem-like cells by affecting iron accumulation.Semantic proximity Read ↗

Concise Review: Emerging Role of CD44 in Cancer Stem Cells: A Promising Biomarker and Therapeutic TargetSemantic proximity Read ↗

Unraveling the underlying mechanisms of cancer stem cells in therapeutic resistance for optimizing treatment strategiesSemantic proximity Read ↗

Proteomic profiling of cancer stem cells derived from primary tumors of HER2/Neu transgenic miceSemantic proximity Read ↗

Unraveling the triad of hypoxia, cancer cell stemness, and drug resistanceSemantic proximity Read ↗

Redox Regulation of Stem-like Cells Though the CD44v-xCT Axis in Colorectal Cancer: Mechanisms and Therapeutic ImplicationsSemantic proximity Read ↗

Drug and apoptosis resistance in cancer stem cells (CSCs): A puzzle with many piecesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.