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Article

Intra-tumor heterogeneity in TP53 null High Grade Serous Ovarian Carcinoma progression.

BMC cancer - 30 Nov 2015

Mota Alba, Triviño Juan Carlos, Rojo-Sebastian Alejandro, Martínez-Ramírez Ángel, Chiva Luis, González-Martín Antonio, Garcia Juan F, Garcia-Sanz Pablo, Moreno-Bueno Gema

Abstract excerpt

BACKGROUND: High grade serous ovarian cancer is characterised by high initial response to chemotherapy but poor outcome in the long term due to acquired resistance. One of the main genetic features of this disease is TP53 mutation. The majority of TP53 mutated tumors harbor missense mutations in this gene, correlated with p53 accumulation. TP53 null tumors constitute a specific subgroup characterised by nonsense,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26620706
DOI: 10.1186/s12885-015-1952-z
PMCID: PMC4666042

Genes

GPNMB
TFDP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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