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Article

Diametric gene-dosage effects as windows into neurogenetic architecture.

Current opinion in neurobiology - 1 Feb 2013

Crespi Bernard

Abstract excerpt

Gene expression can be modulated in two opposite directions, towards higher or lower amounts of product. How do diametric changes in gene dosage influence neurological development and function? Recent studies of transgenic and knockout mouse models, genomic copy-number variants, imprinted-gene expression alterations, and sex-chromosome aneuploidies are revealing examples of 'mirror-extreme' brain and behavior...

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PMID: 22995549
DOI: 10.1016/j.conb.2012.08.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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