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Article

Determinants of pleiotropy and monotonic gene dosage responses across human traits

2025-02-26

Abstract excerpt

<h4>ABSTRACT</h4> Pleiotropic effects of gene dosage are central to understanding comorbidities in developmental pediatric and psychiatric disorders, yet the underlying biological processes are unknown. We developed Functional Burden analysis (FunBurd) to investigate the association of all protein-coding copy-number-variants (CNVs), genome-wide, with 43 complex traits in ∼500,000 UK-Biobank participants. We teste...

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Literature Corpus work
fbe8233e-e034-5797-a6c0-4c693b250148
DOI
10.1101/2025.02.25.25322833
Open publication

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Determinants of pleiotropy and monotonic gene dosage responses across human traitsDOI 10.1101/2025.02.25.25322833
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