Article

The variegation of human brain vulnerability to rare genetic disorders and convergence with behaviorally defined disorders

2022-11-13

Abstract excerpt

Diverse gene dosage disorders (GDDs) increase risk for psychiatric impairment, but characterization of GDD effects on the human brain has so far been piecemeal and lacked simultaneous analysis of multiple brain features across different GDDs. Here, through multimodal neuroimaging of 3 aneuploidy syndromes (XXY, XYY, trisomy 21), we reveal considerable diversity in cortical changes across GDDs and imaging-derived p...

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Literature Corpus work: 3d1eb145-4059-5adf-9259-a6028b444c03
DOI: 10.1101/2022.11.12.516252

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