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Article

Elevated blood pressure in cytochrome P4501A1 knockout mice is associated with reduced vasodilation to omega-3 polyunsaturated fatty acids.

Toxicology and applied pharmacology - 1 Nov 2012

Agbor Larry N, Walsh Mary T, Boberg Jason R, Walker Mary K

Abstract excerpt

In vitro cytochrome P4501A1 (CYP1A1) metabolizes omega-3 polyunsaturated fatty acids (n-3 PUFAs); eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), primarily to 17,18-epoxyeicosatetraenoic acid (17,18-EEQ) and 19,20-epoxydocosapentaenoic acid (19,20-EDP), respectively. These metabolites have been shown to mediate vasodilation via increases in nitric oxide (NO) and activation of potassium channels. We...

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Identifiers

PMID: 22995157
DOI: 10.1016/j.taap.2012.09.007
PMCID: PMC3494483

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