A new oxidative sensing and regulation pathway mediated by the MgrA homologue SarZ in <i>Staphylococcus aureus</i>

Abstract excerpt

Oxidative stress serves as an important host/environmental signal that triggers a wide range of responses from the human pathogen Staphylococcus aureus. Among these, a thiol-based oxidation sensing pathway through a global regulator MgrA controls the virulence and antibiotic resistance of the bacterium. Herein, we report a new thiol-based oxidation sensing and regulation system that is mediated through a parallel...