Article
Estimation of population allele frequencies from next-generation sequencing data: pool-versus individual-based genotyping.
Molecular ecology - 1 Jul 2013
Gautier Mathieu, Foucaud Julien, Gharbi Karim, Cézard Timothée, Galan Maxime, Loiseau Anne, Thomson Marian, Pudlo Pierre, Kerdelhué Carole, Estoup Arnaud
Abstract excerpt
Molecular markers produced by next-generation sequencing (NGS) technologies are revolutionizing genetic research. However, the costs of analysing large numbers of individual genomes remain prohibitive for most population genetics studies. Here, we present results based on mathematical derivations showing that, under many realistic experimental designs, NGS of DNA pools from diploid individuals allows to estimate...
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