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Article

Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3 <sup>+</sup> regulatory T cells

18 Sept 2012

Abstract excerpt

Several lines of evidence suggest nuclear factor of activated T-cells (NFAT) to control regulatory T cells: thymus-derived naturally occurring regulatory T cells (nTreg) depend on calcium signals, the Foxp3 gene harbors several NFAT binding sites, and the Foxp3 (Fork head box P3) protein interacts with NFAT. Therefore, we investigated the impact of NFAT on Foxp3 expression. Indeed, the generation of peripherally...

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PMID: 22991461
DOI: 10.1073/pnas.1203870109

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