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Article

Regulation of Pathogenic T Helper 17 Cell Differentiation by Steroid Receptor Coactivator-3

1 May 2018

Abstract excerpt

T helper 17 (Th17) cell development is programmed by the orphan nuclear receptor RORγt, but the underlying mechanism is not well understood. Nuclear receptor-mediated transcriptional activation depends on coactivators. Here, we show that steroid receptor coactivator-3 (SRC-3) critically regulates Th17 cell differentiation. Reduced incidence of experimental autoimmune encephalitis (EAE) associated with decreased...

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PMID: 29791844
DOI: 10.1016/j.celrep.2018.04.088

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