Internal binding sites for MSH: analyses in wild-type and variant Cloudman melanoma cells.

Abstract excerpt

Cloudman S91 mouse melanoma cells express both external (plasma membrane) and internal binding sites for MSH. Using 125I-beta melanotropin (beta-MSH) as a probe, we report here an extensive series of studies on the biological relevance of these internal sites. Cells were swollen in a hypotonic bu...

Topics

• Animals
• Binding Sites
• Biomarkers, Tumor
• Centrifugation, Density Gradient
• Genetic Variation
• Iodine Radioisotopes
• Melanocyte-Stimulating Hormones
• Melanoma
• Mice
• Phenotype
• Receptors, Pituitary Hormone
• Tumor Cells, Cultured