Article
[Inhibition of human MS and BRO melanoma cell proliferation by alpha melanocyte stimulating hormone].
Voprosy meditsinskoi khimii - 1 Jan 2000
Sukhanov V A, Morozova L F, Lalaev V V, Iakh''iaev A V, D'iakov V L
Abstract excerpt
Effect of alpha-melanocyte stimulating hormone (MSH) on proliferating activity of MS and BRO melanoma cell strains with dissimilar phenotype was studied. MSH, apart from the effect on melanomagenesis, influenced the cell proliferation. Growth of MS cells was inhibited at 10(-8)-10(-9) M concentrations of the hormone (IC50 = 2.10(-8) M), while BRO cells were activated. The higher concentrations of MSH inhibited...
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