Article
Melanoma x macrophage fusion hybrids acquire increased melanogenesis and metastatic potential: altered N-glycosylation as an underlying mechanism.
Pigment cell research - 1 Oct 1998
Sodi S A, Chakraborty A K, Platt J T, Kolesnikova N, Rosemblat S, Keh-Yen A, Bolognia J L, Rachkovsky M L, Orlow S J, Pawelek J M
Abstract excerpt
We recently reported that a majority of hybrids generated in vitro between weakly metastatic mouse Cloudman S91 melanoma cells and human or mouse macrophages showed enhanced metastatic potential. With few exceptions, hybrids with enhanced metastatic potential also had elevated basal melanin conte...
Topics
- Animals
- Cells, Cultured
- Glucosamine
- Glycosylation
- Humans
- Hybrid Cells
- Immunoblotting
- Macrophages
- Melanins
- Melanoma
- Melanosomes
- Mice
- Monophenol Monooxygenase
- Neoplasm Metastasis
- Phenotype