Article
Identification by polymerase chain reaction and hybridization with sequence-specific oligoprobes and complete exon-2 cDNA sequencing of a new DRB1 (DRB1*1131) allele.
Tissue antigens - 1 Jul 1997
Balas A, Santos S, Garciá-Sánchez F, Garciá-Escribano C, Merino J L, Vicario J L
Abstract excerpt
HLA-DRB1 is the most polymorphic gene described so far, and their encoded molecules disclose a major role in allogeneic responses. We describe in this report a new DRB1 allele in a Spanish Caucasian bone marrow donor, initially defined by PCR-SSO as a DRB1*11-like allele. Complete exon 2 cDNA-seq...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- Cell Line, Transformed
- DNA, Complementary
- Exons
- HLA-DR Antigens
- HLA-DRB1 Chains
- Humans
- Molecular Sequence Data
- Nucleic Acid Hybridization
- Oligonucleotide Probes
- Polymerase Chain Reaction