Article
Inhibition of the multiple antibiotic resistance (mar) operon in Escherichia coli by antisense DNA analogs.
Antimicrobial agents and chemotherapy - 1 Dec 1997
White D G, Maneewannakul K, von Hofe E, Zillman M, Eisenberg W, Field A K, Levy S B
Abstract excerpt
The multiple antibiotic resistance operon (marORAB) in Escherichia coli controls intrinsic susceptibility and resistance to multiple, structurally different antibiotics and other noxious agents. A plasmid construct with marA cloned in the antisense direction reduced LacZ expression from a constit...
Topics
- Cloning, Molecular
- DNA, Antisense
- Drug Resistance, Multiple
- Escherichia coli
- Lac Operon
- Mutation
- Norfloxacin
- Oligonucleotides, Antisense
- Operon
- Protein Biosynthesis
- Salicylates
- Salicylic Acid
- Thionucleotides
- beta-Galactosidase