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Article

Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomers.

Journal of virology - 1 Aug 2005

Neuman Benjamin W, Stein David A, Kroeker Andrew D, Churchill Michael J, Kim Alice M, Kuhn Peter, Dawson Philip, Moulton Hong M, Bestwick Richard K, Iversen Patrick L, Buchmeier Michael J

Abstract excerpt

The recently emerged severe acute respiratory syndrome coronavirus (SARS-CoV) is a potent pathogen of humans and is capable of rapid global spread. Peptide-conjugated antisense morpholino oligomers (P-PMO) were designed to bind by base pairing to specific sequences in the SARS-CoV (Tor2 strain) genome. The P-PMO were tested for their capacity to inhibit production of infectious virus as well as to probe the...

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Identifiers

PMID: 16014928
DOI: 10.1128/JVI.79.15.9665-9676.2005
PMCID: PMC1181598

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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