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Article

Deficiency of the promyelocytic leukemia protein fosters hepatitis C-associated hepatocarcinogenesis in mice.

PloS one - 1 Jan 2012

Herzer Kerstin, Carbow Anna, Sydor Svenja, Sowa Jan-Peter, Biesterfeld Stefan, Hofmann Thomas-Georg, Galle Peter-Robert, Gerken Guido, Canbay Ali

Abstract excerpt

Overwhelming lines of epidemiological evidence have indicated that persistent infection with hepatitis C virus (HCV) is a major risk for the development of hepatocellular carcinoma (HCC). We have recently shown that HCV core protein mediates functional inactivation of the promyelocytic leukemia (PML) tumor suppressor pathway. However, the role of PML in HCC development yet remains unclear. To clarify the function...

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Share to Gene Expression Regulation, Viral
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22984515
DOI: 10.1371/journal.pone.0044474
PMCID: PMC3439406

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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