Article
Overexpression of the cholesterol-binding protein MLN64 induces liver damage in the mouse.
World journal of gastroenterology - 14 Jun 2007
Tichauer Juan-Enrique, Morales Maria-Gabriela, Amigo Ludwig, Galdames Leopoldo, Klein Andres, Quinones Veronica, Ferrada Carla, Alvarez Alejandra-R, Rio Marie-Christine, Miquel Juan-Francisco, Rigotti Attilio, Zanlungo Silvana
Abstract excerpt
AIM: To examine the in vivo phenotype associated with hepatic metastatic lymph node 64 (MLN64) over-expression. METHODS: Recombinant-adenovirus-mediated MLN64 gene transfer was used to overexpress MLN64 in the livers of C57BL/6 mice. We measured the effects of MLN64 overexpression on hepatic cholesterol content, bile flow, biliary lipid secretion and apoptosis markers. For in vitro studies cultured CHO cells with...
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