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Article

Rapid variance components-based method for whole-genome association analysis.

Nature genetics - 1 Oct 2012

Svishcheva Gulnara R, Axenovich Tatiana I, Belonogova Nadezhda M, van Duijn Cornelia M, Aulchenko Yurii S

Abstract excerpt

The variance component tests used in genome-wide association studies (GWAS) including large sample sizes become computationally exhaustive when the number of genetic markers is over a few hundred thousand. We present an extremely fast variance components-based two-step method, GRAMMAR-Gamma, deve...

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PMID: 22983301
DOI: 10.1038/ng.2410

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22983301-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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