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Article

Influence of acquired β-lactamases on the evolution of spontaneous carbapenem resistance in Escherichia coli.

The Journal of antimicrobial chemotherapy - 1 Jan 2013

Adler Marlen, Anjum Mehreen, Andersson Dan I, Sandegren Linus

Abstract excerpt

OBJECTIVES: To investigate the influence of plasmid-borne β-lactamases on the evolution of spontaneous carbapenem resistance in Escherichia coli and the fitness costs associated with resistance. METHODS: Stepwise selection of carbapenem-resistant mutants with or without the extended-spectrum β-lactamase (ESBL)-encoding plasmid pUUH239.2 was performed. Mutation rates and mutational pathways to resistance were...

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Identifiers

PMID: 22977158
DOI: 10.1093/jac/dks368

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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