Article
Impact of the phenotypic expression of temocillin resistance in Escherichia coli on temocillin efficacy in a murine peritonitis model.
The Journal of antimicrobial chemotherapy - 2 May 2024
Mallart Elise, Guerin François, Amoura Ariane, Le Scouarnec Matthieu, Hamon Antoine, El Meouche Imane, Chau Françoise, Lefort Agnès, Fantin Bruno, Cattoir Vincent, de Lastours Victoire
Abstract excerpt
BACKGROUND: Temocillin is a narrow spectrum β-lactam active against MDR Enterobacterales. Mechanisms of acquired resistance to temocillin are poorly understood. We analysed resistance mechanisms in clinical isolates of Escherichia coli and evaluated their impact on temocillin efficacy in vitro and in a murine peritonitis model. METHODS: Two sets of isogenic clinical E. coli strains were studied: a susceptible...
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