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Article

Acquisition of Carbapenem Resistance by Plasmid-Encoded-AmpC-Expressing Escherichia coli.

Antimicrobial agents and chemotherapy - 1 Jan 2017

van Boxtel Ria, Wattel Agnes A, Arenas Jesús, Goessens Wil H F, Tommassen Jan

Abstract excerpt

Although AmpC β-lactamases can barely degrade carbapenems, if at all, they can sequester them and prevent them from reaching their targets. Thus, carbapenem resistance in Escherichia coli and other Enterobacteriaceae can result from AmpC production and simultaneous reduction of antibiotic influx into the periplasm by mutations in the porin genes. Here we investigated the route and genetic mechanisms of...

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Identifiers

PMID: 27799202
DOI: 10.1128/AAC.01413-16
PMCID: PMC5192137

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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