Article
Mechanisms and convergence of compensatory evolution in mammalian mitochondrial tRNAs.
Nature genetics - 1 Nov 2004
Kern Andrew D, Kondrashov Fyodor A
Abstract excerpt
The function of protein and RNA molecules depends on complex epistatic interactions between sites. Therefore, the deleterious effect of a mutation can be suppressed by a compensatory second-site substitution. In relating a list of 86 pathogenic mutations in human tRNAs encoded by mitochondrial genes to the sequences of their mammalian orthologs, we noted that 52 pathogenic mutations were present in normal tRNAs...
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