Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanisms and convergence of compensatory evolution in mammalian mitochondrial tRNAs.

Nature genetics - 1 Nov 2004

Kern Andrew D, Kondrashov Fyodor A

Abstract excerpt

The function of protein and RNA molecules depends on complex epistatic interactions between sites. Therefore, the deleterious effect of a mutation can be suppressed by a compensatory second-site substitution. In relating a list of 86 pathogenic mutations in human tRNAs encoded by mitochondrial ge...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Mitochondrial
Share to Epistasis, Genetic
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mammals

Share to Nucleic Acid Conformation

Share to RNA, Mitochondrial

Share to RNA, Transfer

Source

Identifiers

PMID: 15502829
DOI: 10.1038/ng1451

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15502829-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanisms and convergence of compensatory evolution in mammalian mitochondrial tRNAs.PMID 15502829Read ↗

Evolution meets disease: penetrance and functional epistasis of mitochondrial tRNA mutations.Semantic proximity Read ↗

Prediction of pathogenic mutations in mitochondrially encoded human tRNAs.Semantic proximity Read ↗

Intra-protein compensatory mutations analysis highlights the tRNA recognition regions in aminoacyl-tRNA synthetases.Semantic proximity Read ↗

Compensatory evolution in mitochondrial tRNAs navigates valleys of low fitness.Semantic proximity Read ↗

Functional defects of pathogenic human mitochondrial tRNAs related to structural fragility.Semantic proximity Read ↗

Assigning pathogenicity to mitochondrial tRNA mutations: when "definitely maybe" is not good enough.Semantic proximity Read ↗

Relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs.Semantic proximity Read ↗

A model of compensatory molecular evolution involving multiple sites in RNA molecules.Semantic proximity Read ↗

Coevolution in RNA molecules driven by selective constraints: evidence from 5S rRNA.Semantic proximity Read ↗

Functional recurrent mutations in the human mitochondrial phylogeny: dual roles in evolution and disease.Semantic proximity Read ↗

Epistatic interactions modulate the evolution of mammalian mitochondrial respiratory complex components.Semantic proximity Read ↗

Mitonuclear Compensatory Coevolution.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.