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Article

RNA sequence evolution with secondary structure constraints: comparison of substitution rate models using maximum-likelihood methods.

Genetics - 1 Jan 2001

Savill N J, Hoyle D C, Higgs P G

Abstract excerpt

We test models for the evolution of helical regions of RNA sequences, where the base pairing constraint leads to correlated compensatory substitutions occurring on either side of the pair. These models are of three types: 6-state models include only the four Watson-Crick pairs plus GU and UG; 7-state models include a single mismatch state that combines all of the 10 possible mismatches; 16-state models treat all...

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Identifiers

PMID: 11139520
DOI: 10.1093/genetics/157.1.399
PMCID: PMC1461489

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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