Article

Adaptation of CD4 in gorillas and chimpanzees conveyed resistance to simian immunodeficiency viruses

2023-11-13

Abstract excerpt

Simian immunodeficiency viruses (SIVs) comprise a large group of primate lentiviruses that endemically infect African monkeys. HIV-1 spilled over to humans from this viral reservoir, but the spillover did not occur directly from monkeys to humans. Instead, a key event was the introduction of SIVs into great apes, which then set the stage for infection of humans. Here, we investigate the role of the lentiviral entr...

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Literature Corpus work: 35094704-dcfd-50c8-b6a0-1a4aa71b7367
DOI: 10.1101/2023.11.13.566830

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