Article
CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses.
Proceedings of the National Academy of Sciences of the United States of America - 30 Mar 2021
Russell Ronnie M, Bibollet-Ruche Frederic, Liu Weimin, Sherrill-Mix Scott, Li Yingying, Connell Jesse, Loy Dorothy E, Trimboli Stephanie, Smith Andrew G, Avitto Alexa N, Gondim Marcos V P, Plenderleith Lindsey J, Wetzel Katherine S, Collman Ronald G, Ayouba Ahidjo, Esteban Amandine, Peeters Martine, Kohler William J, Miller Richard A, François-Souquiere Sandrine, Switzer William M, Hirsch Vanessa M, Marx Preston A, Piel Alex K, Stewart Fiona A, Georgiev Alexander V, Sommer Volker, Bertolani Paco, Hart John A, Hart Terese B, Shaw George M, Sharp Paul M, Hahn Beatrice H
Abstract excerpt
Infection with human and simian immunodeficiency viruses (HIV/SIV) requires binding of the viral envelope glycoprotein (Env) to the host protein CD4 on the surface of immune cells. Although invariant in humans, the Env binding domain of the chimpanzee CD4 is highly polymorphic, with nine coding variants circulating in wild populations. Here, we show that within-species CD4 diversity is not unique to chimpanzees...
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