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Article

DNA methyltransferase 1 (Dnmt1) mutation affects Snrpn imprinting in the mouse male germ line.

Genome - 1 Sept 2012

Saferali Aabida, Moussette Sanny, Chan Donovan, Trasler Jacquetta, Chen Taiping, Rozen Rima, Naumova Anna K

Abstract excerpt

DNA methylation and DNA methyltransferases are essential for spermatogenesis. Mutations in the DNA methyltransferase Dnmt1 gene exert a paternal effect on epigenetic states and phenotypes of offspring, suggesting that DNMT1 is important for the epigenetic remodeling of the genome that takes place during spermatogenesis. However, the specific role of DNMT1 in spermatogenesis and the establishment of genomic...

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Identifiers

PMID: 22967183
DOI: 10.1139/g2012-056

Genes

DNMT1

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