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Epigenetic regulation of brain development, plasticity, and response to early-life stress

6 Aug 2025

Abstract excerpt

Brain development is choreographed by complex gene programs, regulated in turn by epigenetic mechanisms. Far from being complete at birth, both the brain and epigenome continue to mature postnatally. Recent research has found postnatal maturation of the epigenome-including cell-type specific patterns of DNA methylation, chromatin modifications, and non-coding RNAs-to be largely complete by the peri-adolescent...

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PMID: 40770493
DOI: 10.1038/s41386-025-02179-z

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