Article

Restoration of early postnatal synaptic dysregulation rescues polyglutamine-mediated motor neuron degeneration in mice

2024-06-12

Abstract excerpt

<title>Abstract</title> Spinal and bulbar muscular atrophy (SBMA) is an adult-onset neurodegenerative disorder caused by the expansion of a polyglutamine tract in the androgen receptor (AR). Here, we show that polyglutamine-expanded AR accumulates in the nucleus of motor neurons and induces aberrant up-regulation of glutamatergic synaptic genes, mediated by a master transcriptional repressor, Rest, during earl...

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Literature Corpus work: cf5f59ca-d950-5d48-b6e6-cb89375a4b1e
DOI: 10.21203/rs.3.rs-4526507/v1

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