A unique recombination event resulting in a C4A*Q0,C4B*Q0 double null haplotype.

doi:10.1172/JCI115978

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Article

A unique recombination event resulting in a C4AQ0,C4BQ0 double null haplotype.

The Journal of clinical investigation - 1 Oct 1992

Fasano M B, Winkelstein J A, LaRosa T, Bias W B, McLean R H

Abstract excerpt

The fourth component of complement (C4) is encoded by two closely linked genes (C4A and C4B) within the MHC. Null alleles at either locus (C4AQ0 or C4BQ0) are relatively common, occurring at the C4A locus in approximately 10% of normal individuals and at the C4B locus in approximately 16% of norm...

Topics

Blotting, Southern
Child
Chromosome Mapping
Complement C4
Haplotypes
Humans
Male
Phenotype
Recombination, Genetic
Steroid 21-Hydroxylase

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