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Article

Epithelial-mesenchymal transition-like phenotypic changes of retinal pigment epithelium induced by TGF-β are prevented by PPAR-γ agonists.

Investigative ophthalmology & visual science - 5 Oct 2012

Hatanaka Hiroki, Koizumi Noriko, Okumura Naoki, Kay EunDuck P, Mizuhara Eri, Hamuro Junji, Kinoshita Shigeru

Abstract excerpt

PURPOSE: Proliferative eye diseases, such as proliferative vitreoretinopathy and proliferative diabetic retinopathy, are caused partly by fibrotic change of retinal pigment epithelial cells (RPECs). The purpose of our study was to examine the effect of the peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist on the fibrotic change of primate RPECs. METHODS: Monkey RPECs (MRPECs) isolated from a...

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PMID: 22956604
DOI: 10.1167/iovs.12-10488

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RPE65

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