Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of pirfenidone on TGF-beta2 induced proliferation, migration and epithlial-mesenchymal transition of human lens epithelial cells line SRA01/04.

PloS one - 1 Jan 2013

Yang Yangfan, Ye Yiming, Lin Xianchai, Wu Kaili, Yu Minbin

Abstract excerpt

BACKGROUND: Posterior capsular opacification (PCO) is a common complication of cataract surgery. Transforming growth factor-β2 (TGF-β2) plays important roles in the development of PCO. The existing pharmacological treatments are not satisfactory and can have toxic side effects. METHODOLOGIES/PRINCIPAL FINDINGS: We evaluated the effect of pirfenidone on proliferation, migration and epithlial-mesenchymal transition...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Cell Line, Transformed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial Cells

Share to Epithelial-Mesenchymal Transition

Share to Lens, Crystalline

Share to Pyridones

Share to Smad Proteins

Share to Transforming Growth Factor beta2

Source

Open in PubMed Open full text

Identifiers

PMID: 23437252
DOI: 10.1371/journal.pone.0056837
PMCID: PMC3578851

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of pirfenidone on TGF-beta2 induced proliferation, migration and epithlial-mesenchymal transition of human lens epithelial cells line SRA01/04.PMID 23437252Read ↗

Silibinin Prevents TGFβ-Induced EMT of RPE in Proliferative Vitreoretinopathy by Inhibiting Stat3 and Smad3 PhosphorylationSemantic proximity Read ↗

Dual function of TGFβ in lens epithelial cell fate: implications for secondary cataractSemantic proximity Read ↗

Surviving Fibroblasts After Treatment With Mitomycin C Exhibit SASP-Like Phenotype After Glaucoma Filtration Surgery.Semantic proximity Read ↗

Systematic Analysis of Transcriptomic Profile of the Effects of Low Dose Atropine Treatment on Scleral Fibroblasts using Next-Generation Sequencing and BioinformaticsSemantic proximity Read ↗

β-Catenin/Smad3 Interaction Regulates Transforming Growth Factor-β-Induced Epithelial to Mesenchymal Transition in the LensSemantic proximity Read ↗

TGF-β-SNAIL axis induces Müller glial-mesenchymal transition in the pathogenesis of idiopathic epiretinal membraneSemantic proximity Read ↗

TGF-β/Smad Signalling Activation by HTRA1 Regulates the Function of Human Lens Epithelial Cells and Its Mechanism in Posterior Subcapsular Congenital CataractSemantic proximity Read ↗

MicroRNA-204-5p Regulates Epithelial-to-Mesenchymal Transition during Human Posterior Capsule Opacification by Targeting SMAD4Semantic proximity Read ↗

Fibroblast-matrix interplay: Nintedanib and pirfenidone modulate the effect of IPF fibroblast-conditioned matrix on normal fibroblast phenotype.Semantic proximity Read ↗

TLR3 Gene Regulates Cataract-Related Mechanisms Through The Jagged-1/Notch Signaling PathwaySemantic proximity Read ↗

EGF-Induced Cell Migration Is Mediated by ERK and PI3K/AKT Pathways in Cultured Human Lens Epithelial CellsSemantic proximity Read ↗

Transforming growth factor-beta-induced epithelial-mesenchymal transition in the lens: a model for cataract formation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.