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Article

ROCK Inhibitor Y-27632 Promotes Human Retinal Pigment Epithelium Survival by Altering Cellular Biomechanical Properties.

Current molecular medicine - 1 Jan 2017

Ni Y, Qin Y, Fang Z, Zhang Z

Abstract excerpt

PURPOSE: Dysfunction or death of retinal pigment epithelial (RPE) cells is a common pathogenesis of various types of retinal degenerative diseases. Recent reports indicated that ROCK pathway inhibitors regulate cell proliferation or apoptosis in a celltype- dependent manner. Here, we aim to investigate the effect of ROCK inhibitor Y- 27632 on the human retinal pigment epithelium (RPE) in vitro. METHODS: Cell...

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Source

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Identifiers

PMID: 29546834
DOI: 10.2174/1566524018666180316150936
PMCID: PMC6040175

Genes

RPE
AFM
CCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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